SkinPhysio-Extract
Evidence-grounded extraction and provenance auditing of quantitative skin physiology data during a Jagiellonian research visit.
Scientific context
Visiting PhD Researcher, Jagiellonian University Medical College, Department of Social Pharmacy, Faculty of Pharmacy, Kraków, Poland (15 June–14 August 2026).
Hosted by Prof. Barbara Wiśniowska in collaboration with Dr Laura Krumpholz. The visit was supported by a Short-Term Scientific Mission under COST Action CA21108 — NETSKINMODELS, alongside mobility funding.
The original research plan investigated porcine-to-human skin model translation. An initial data-readiness assessment found that compatible paired permeability outcomes and model outputs were not available for defensible validation of transfer learning during the visit. The work therefore focused on a prerequisite for future modelling: reliable extraction and provenance auditing of quantitative skin anatomy and physiology evidence.
SkinPhysio-Extract
The project developed a reproducible, LLM-assisted research workflow for structured evidence extraction from published porcine skin physiology literature, with source identity rules, field-level provenance and numerical quality controls.
Work undertaken
- Audited a published porcine skin anatomy and physiology workbook comprising 14 parameter sheets and 853 records, including 469 formula-derived records.
- Defined canonical record boundaries, parameter schemas, evidence links and deterministic numerical checks.
- Assembled text and image evidence from four development sources.
- Implemented a four-document, three-method development experiment to compare extraction and verification strategies. All 12 experimental cells reached terminal states and passed a result-blind integrity review.
Research status: The development pilot was non-confirmatory because of transport and logging irregularities in the initial run. No confirmatory extraction-performance result or validated pig-to-human transfer-learning model is claimed. The outputs provide a reproducible foundation for future PBPK parameterisation and interspecies skin modelling.