Yu Zhang
PhD Researcher in Chemical and Process Engineering · University of Surrey
Guildford, United Kingdom
School of Chemistry and Chemical Engineering
I develop AI-enabled methods for faster, more reliable skin product formulation design. My PhD research combines probabilistic machine learning, active learning, optimisation, interpretable modelling and automated experimentation with in vitro release and permeation testing.
The long-term goal is an assay-aware digital twin that can learn from limited experimental data, quantify uncertainty, select informative formulations, stop unpromising experiments early and turn data into interpretable scientific knowledge.
Research programme
Measure
IVRT and IVPT experiments generate time-resolved evidence about drug release and permeation from topical formulations.
Learn
Gaussian processes and hybrid models learn formulation-performance relationships while preserving predictive uncertainty.
Decide
Active learning, Bayesian optimisation and early stopping focus each experimental batch on the most useful decisions.
Explain
Domain-constrained symbolic regression and scientific LLMs connect predictions with mechanisms and literature evidence.
Current research directions
- Adaptive formulation optimisation - allocating small experimental batches between performance-seeking and information-seeking candidates.
- Early experimental decision-making - forecasting final outcomes from partial IVPT/IVRT trajectories and controlling false stops.
- Interpretable dynamic modelling - embedding physical and mathematical constraints into symbolic regression for drug-release kinetics.
- Scientific LLM systems - extracting traceable formulation and permeation evidence from literature and building reusable research datasets.
Background
I am a PhD researcher in Chemical and Process Engineering at the University of Surrey, supervised by Professor Tao Chen and Dr Dimitrios Tsaoulidis. Before joining Surrey, I completed an MEng in Control Science and Engineering at China University of Petroleum - Beijing and a BEng in Automation at Panzhihua University.
My earlier work addressed industrial process monitoring, few-shot learning, fault diagnosis and operational optimisation. That background now informs my approach to data-scarce formulation science: models should be useful under real experimental constraints, not only accurate on a tidy benchmark.
news
| Aug 03, 2026 | Our domain knowledge constrained symbolic regression framework for interpretable dermal formulation optimisation is now published in Pharmaceutical Research. Paper |
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| Jul 14, 2026 | Our active learning framework for adaptive dermal formulation optimisation was accepted by Chemical Engineering Research and Design. Paper · Code |
| Jun 06, 2025 | Our early decision-making algorithm for accelerating topical formulation experiments is now available in Computers & Chemical Engineering. Paper · Code |
| Jan 06, 2025 | Started a UK Turing Scheme research placement at West China Hospital, Sichuan University, extending my work on AI-enabled healthcare research. |